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. 2021 Jan 11;11:593225. doi: 10.3389/fphar.2020.593225

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Copyright © 2021 Niu, Li, Song, Liu, Li and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ech mitigates I/R-induced myocardial injury in vivo. MI/R rats were subjected to Ech (20, 40, and 80 mg/kg) treatment before reperfusion. (A) Representative heart sections stained with TTC after MI/R and Ech administration. Myocardial infarction was measured as the proportion of infarct area (white) to the total non-infract area (red) (n = 5). (B, C) The degree of myocardial injury was assessed by measurement of serum LDH and CK-MB levels (n = 5). (D, E) Measurements of myocardial LDH and CK-MB levels in the heart of rats (n = 5). *p < 0.05 and **p < 0.01 compared with MI/R rats.