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. 2021 Jan 21;8:629397. doi: 10.3389/fcell.2020.629397

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Copyright © 2021 Gao, Zhang, Tao, Chen, Liu, Liu, Wu, Yin, Gao, Xie, Yang, Liu, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibiting mitophagy suppressed mitochondrial fission. (A) MitoTracker Deep Red staining in cardiac fibroblasts (CF) transfected with either Pink1 siRNA or negative control (NC) and exposed to TGF-β1. (B) Immunoblotting analysis, with quantification, of mitochondrial fission- and fusion-related proteins among the different groups. Data are shown as mean ± standard error of the mean (n = 3 independent cell isolations per group). Means were compared by one-way ANOVA, followed by the Student–Newman–Keuls (SNK) post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001.