FIGURE 7.
Effects of 8- and 36-day olanzapine treatment on the protein expression of GFAP, S100B, and TLR4 signaling in the hypothalamus. (A–D) Western blot analysis of GFAP, S100B, TLR4, MyD88, phospho-p65, MMP-9, phospho-p38, and phospho-ERK1/2 (44 and 42 kd) protein expression after 8-day olanzapine treatment. (E–H) Western blot analysis of GFAP, S100B, TLR4, MyD88, phospho-p65, MMP-9, phospho-p38, and phospho-ERK1/2 (42/44 kd) protein expression after 36-day olanzapine treatment. All data were presented as mean ± SEM. Statistical significance was defined as p < 0.05 (∗∗∗p < 0.001 vs. control). Con, control; OLZ, olanzapine.