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. 2021 Jan 22;11:602530. doi: 10.3389/fimmu.2020.602530

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Copyright © 2021 Yang, Lode, Berzaghi, Islam, Martinez-Zubiaurre and Hellevik

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Radiation-induced Fas-receptor on cancer-associated fibroblasts (CAFs) and natural killer (NK) cell-mediated killing. Panels in (A) show flow cytometry histograms comparing surface expression of Fas receptor in irradiated and non-irradiated CAFs from a representative donor. Control histograms represent CAFs exposed to isotype control antibodies. (B) Quantitative expression of Fas receptor presented as median fluorescence intensity (MFI) calculated from three independent CAF donors. (C) NK cell cytotoxicity assay measuring NK cell mediated cell killing of irradiated or non-irradiated CAFs as targets, in addition to two different control target cell types at NK to target ratio 5:1. Bars represent mean (± SD) from three independent CAF donors. Statistics and P-values between NF and CAFs were determined using one-way ANOVA with Tukey correction for multiple comparisons. ** indicates P < 0.01.