TABLE 1.
Effect estimates of the associations between genetically predicted linoleic acid (LA) and ischemic stroke and its subtypes.
| Outcomes and methods | Number of SNPs | OR (95% CI) | P-value for association |
| IS | |||
| IVW | 11 | 0.98 (0.97–0.99) | 0.003 |
| MR-Egger | 11 | / | 0.797a |
| Weighted median | 11 | 0.98 (0.97–1.00) | 0.015 |
| Weighted mode-based | 11 | 0.99 (0.97–1.00) | 0.030 |
| MR-PRESSO | 11 | / | 0.838b |
| LAS | |||
| IVW | 11 | 0.95 (0.92–0.98) | 0.004 |
| MR-Egger | 11 | / | 0.060a |
| Weighted median | 11 | 0.94 (0.90–0.97) | 0.001 |
| Weighted mode-based | 11 | 0.94 (0.92–0.95) | 0.002 |
| MR-PRESSO | 11 | / | 0.100b |
| CES | |||
| IVW | 11 | 0.98 (0.96–1.00) | 0.090 |
| MR-Egger | 11 | / | 0.601a |
| Weighted median | 11 | 0.98 (0.96–1.01) | 0.180 |
| Weighted mode-based | 11 | 0.98 (0.96–1.01) | 0.226 |
| MR-PRESSO | 11 | / | 0.571b |
| SVS | |||
| IVW | 11 | 1.01 (0.98–1.04) | 0.340 |
| MR-Egger | 11 | / | 0.864a |
| Weighted median | 11 | 1.02 (0.99–1.05) | 0.201 |
| Weighted mode-based | 11 | 1.02 (0.99–1.05) | 0.320 |
| MR-PRESSO | 11 | / | 0.397b |
CES, cardioembolic stroke; CI, confidence interval; IS, ischemic stroke; IVW, inverse-variance weighted; LA, linoleic acid; LAS, large artery stroke; OR, odds ratio; PRESSO, Pleiotropy RESidual Sum and Outlier; and SVS, small vessel stroke.
aP value for the intercept from MR-Egger regression analysis.
bP value of MR-PRESSO global test.