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. 2021 Jan 22;11:610665. doi: 10.3389/fgene.2020.610665

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Copyright © 2021 Adashev, Kotov, Bazylev, Shatskikh, Aravin and Olenina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical Abstract — The Stellate-Su(Ste) genetic system is maintained only in the D. melanogaster genome. X-linked testis-specific Stellate genes are repressed in the testes of wild-type flies with the aid of piRNAs derived from the homologous Y-linked Su(Ste) locus that is essential for male fertility. Derepression of Stellate genes in the testes of hybrids of D. melanogaster with closely related D. mauritiana leads to the crystalline aggregate formation and causes strong meiotic failures and male hybrid sterility. Thus, the Stellate-Su(Ste) system and the piRNA pathway contribute to the emergence of the reproductive isolation of D. melanogaster from initial species.