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. 2021 Jan 11;14:540669. doi: 10.3389/fncel.2020.540669

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Copyright © 2021 Liang, Song, Chen, Xie, Luo, Su, Zhu, Xu, Liu, Zhu, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Middle cerebral artery occlusion (MCAO)-induced caspase-1 expression in rats. (A,B) Western blotting analysis of the expression of caspase-1 protein in the peri-infarct area. (C) RT-qPCR of caspase-1 mRNA at 12 h to day 7 after MCAO. (D) Representative images of fluorescent staining of caspase-1 (red) and the neuron marker (NeuN, green) in the ipsilateral thalamus after MCAO from day 1 to day 7. Scale bar = 50 μm. (E) Western blot analysis of caspase-1 and NeuN proteins at different concentrations of vx-765. (F) Combined western blotting statistics. All data are expressed as means ± SEM, *P < 0.05 and **P < 0.01, vs. sham, ^#P < 0.05, vs. vehicle; ^▲P > 0.05, vs. vx-765 50 mg/kg, n = 4 per group.