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. 2021 Jan 11;14:540669. doi: 10.3389/fncel.2020.540669

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Copyright © 2021 Liang, Song, Chen, Xie, Luo, Su, Zhu, Xu, Liu, Zhu, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Caspase-1 inhibitor vx-765 reduced cerebral infarct volume and improved neurological deficits in rats following MCAO. (A–C) Neurological deficit scores estimated using Garcia scores, forelimb placing scores, and time of rod from 6 h to day 3 after MCAO. n = 35 per group. (D) 2,3,5-Triphenyltetrazolium Chloride (TTC) staining of the infarct area at day 3 after MCAO. (E) Corresponding statistical analyses of the infarct area. Scale bar = 2 mm, n = 3 per group. Data are shown as means ± SEM, *P < 0.05 and **P < 0.01, vs. sham; ^#P < 0.05 and ^##P < 0.01, vs. vehicle.