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. 2021 Jan 11;14:540669. doi: 10.3389/fncel.2020.540669

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Copyright © 2021 Liang, Song, Chen, Xie, Luo, Su, Zhu, Xu, Liu, Zhu, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of tight junction (TJ) proteins after caspase-1 inhibition by vx-765, following ischemic stroke. (A) Immunofluorescence staining of CD31 (green) in the peri-infarct regions. Scale bar = 50 μm. (B) Fluorescence intensity and corresponding statistics. (C) Western blotting of the amount of zonula occludens-1 (ZO-1), occludin, and claudin-5 proteins in the peri-infarct area and (D) corresponding statistics. (E) Immunoblot images of the expression of glucose transporter protein-1 (GLUT-1) and osteopontin (OPN) in the peri-infarct regions, with (F) corresponding statistical analyses. Data are expressed as means ± SEM, *P < 0.05 and **P < 0.01, vs. sham; ^#P < 0.05, vs. vehicle, n = 6 per group.