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. 2021 Jan 11;14:540669. doi: 10.3389/fncel.2020.540669

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Copyright © 2021 Liang, Song, Chen, Xie, Luo, Su, Zhu, Xu, Liu, Zhu, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BBB function after inhibition of the receptor for advanced glycation end products (RAGE)/mitogen-activated protein kinase (MAPK) pathway after MCAO. (A) Representative immunofluorescence images of RAGE staining (red) in the peri-infarct regions. Scale bar = 50 μm. (B) Fluorescence intensity and the corresponding data analysis. (C) Western blot on the expression of RAGE, AGE, high-mobility family box-1 protein (HMGB1), S100B, and β-actin, with (D) the corresponding statistics. (E) Protein expressions of p-ERK/ERK, p-P38/P38, p-JNK/JNK, p-NF-κB/NF-κB, p-IκBa/IκBa, and β-actin as detected by western blotting, with (F) corresponding statistics. All data are expressed as means ± SEM, *P < 0.05 and **P < 0.01, vs. sham; ^#P < 0.05 and ^##P < 0.01, vs. vehicle, n = 6 per group.