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. 2021 Jan 11;14:540669. doi: 10.3389/fncel.2020.540669

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Copyright © 2021 Liang, Song, Chen, Xie, Luo, Su, Zhu, Xu, Liu, Zhu, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of caspase-1 inhibition on ischemia and neuronal damage. Caspase-1 is generated and activated by NLRP3 inflammasome, ASC, and pro-caspase-1 following cerebral infarction. And it matures IL-1β and IL-18 and triggers GSDMD-induced pyroptosis, which facilitates increased MMPs and decreased TJ proteins, TIMP expression, and changes in BBB permeability. vx-765 improved the ischemia-induced BBB disruption through upregulating the expression of TJ proteins and TIMPs and suppressing the expression of MMPs, modulating the pyroptosis activation and RAGE/MAPK pathway.