Table 3.
Interstitial PO2 kinetics parameters during 180 s twitch contractions and 240 s recovery during control and local KATP channel inhibition
| Mixed gastrocnemius |
||
|---|---|---|
| Control | Glibenclamide | |
| Pre-superfusion PO2is (mmHg) | – | 13.8 ± 3.4 |
| PO2isBL (mmHg) | 14.1 ± 1.4 | 12.8 ± 3.6 * |
| Δ1PO2is (mmHg) | 8.2 ± 1.5 | 8.1 ± 3.1 |
| TD (s) | 8.0 ± 4.3 | 5.2 ± 3.2 * |
| τ (s) | 14.1 ± 2.7 | 12.2 ± 3.0 |
| MRT (s) | 22.2 ± 4.7 | 17.3 ± 4.3 * |
| PO2isnadir (mmHg) | 5.9 ± 0.9 | 4.7 ± 1.1 * |
| Δ2PO2is (mmHg) | 1.4 ± 0.9 | 1.4 ± 0.8 |
| PO2isend (mmHg) | 7.3 ± 1.5 | 6.1 ± 1.4 |
| Δ1PO2is/τ (mmHg s−1) | 0.60 ± 0.16 | 0.72 ± 0.36 |
| Recovery T63 (s) | 95 ± 19 | 118 ± 20 * |
| Recovery PO2is (mmHg) | 14.6 ± 4.0 | 15.3 ± 6.5 |
| Δ3PO2is/T63 (mmHg s−1) | 0.07 ± 0.03 | 0.08 ± 0.04 |
PO2is BL, resting baseline; PO2is; Δ1PO2is and Δ2PO2is, amplitude of the first and second components, respectively; TD, time delay; τ, time constant; MRT, mean response time; PO2is nadir, lowest response prior to secondary rise in PO2is; PO2is end, PO2is at the end of contractions; Δ1PO2is/τ, rate of PO2is fall; T63, time to reach 63% of final response; Δ3PO2is/T63, rate of PO2is recovery. Data are means ± SD and compared via two-tail paired t tests.
*
P < 0.05 vs. control.