Table 1.
Longitudinal Cohort of Subjects with CF Analyzed from January 1, 2004, to December 31, 2017
| Patients without Quantitative Cultures (Total = 66) | Patients with 1–9 Quantitative Cultures (Total = 137) | Patients with ≥10 Quantitative Cultures (Total = 134) | |
|---|---|---|---|
| Sex and genotypes, n (%) | |||
| Sex, F | 31 (47.0) | 68 (49.6) | 61 (45.5) |
| F508del/F508del | 32 (48.5) | 65 (47.4) | 79 (59.0) |
| F508del/other | 26 (39.4) | 57 (41.6) | 47 (35.1) |
| Age, yr, median (IQR) | |||
| Birth year | 2007 (1992–2013) | 1999 (1986–2007) | 1986 (1976–1997) |
| At first culture* | 3.40 (0.30–19.10) | 8.84 (0.31–23.72) | 19.34 (8.08–28.48) |
| At first quantitative culture | — | 11.21 (2.23–24.33) | 19.66 (8.69–28.48) |
| Follow-up duration, median (IQR) | |||
| Years between first and last cultures* | 1.25 (0.52–3.68) | 5.48 (2.66–9.72) | 11.98 (7.94–13.57) |
| Years between first and last quantitative cultures | — | 2.08 (0.00–4.47) | 10.15 (6.73–11.84) |
| Number of cultures* | 7 (3–14) | 14 (5–28) | 35 (26–41) |
| Number of quantitative cultures | — | 2 (1–5) | 25 (17–33) |
| Final clinical status, n (%) | |||
| Lung transplant | 0 (0) | 7 (5.1) | 24 (17.9) |
| Death without transplant | 1 (1.5) | 7 (5.1) | 14 (10.4) |
| Alive, no transplant, and cultured after January 1, 2016 | 53 (80.3) | 92 (67.2) | 92 (68.7) |
| Other (e.g., transfer of care) | 12 (18.2) | 31 (22.6) | 4 (3.0) |
| Culture results, median (IQR)* | |||
| Any S. aureus | 50 (75.8) | 120 (87.6) | 126 (94.0) |
| MSSA | 46 (69.7) | 100 (73.0) | 111 (82.8) |
| MRSA | 5 (7.6) | 64 (46.7) | 79 (59.0) |
| P. aeruginosa | 34 (51.5) | 101 (73.7) | 128 (95.5) |
| Either S. aureus or P. aeruginosa | 59 (89.4) | 133 (97.1) | 134 (100) |
| Both S. aureus and P. aeruginosa | 25 (37.9) | 88 (64.2) | 120 (89.6) |
| Simultaneous S. aureus and P. aeruginosa | 21 (31.8) | 71 (51.8) | 114 (85.1) |
Definition of abbreviations: CF = cystic fibrosis; IQR = interquartile range; MRSA = methicillin-resistant S. aureus; MSSA = methicillin-sensitive S. aureus; P. aeruginosa = Pseudomonas aeruginosa; S. aureus = Staphylococcus aureus.
*
Includes nonquantitative CF respiratory culture studies such as oropharyngeal swab in addition to quantitative cultures. All cultures obtained after lung transplant were excluded.