Figure 2.

Relative frequency of TERT alterations in multiple tumor types. A–F: The relative frequency of TERT promoter mutations and amplifications in nonmelanoma skin cancer (A), melanoma (B), gliomas (C), genitourinary neoplasia, including urothelial carcinoma (D), thyroid carcinoma (E), and miscellaneous tumor types (F) is depicted. C:TERT alterations in high- and low-grade gliomas are further stratified on the basis of IDH1 mutation status. The papillary thyroid carcinoma category includes all well-differentiated subtypes and excludes the tall cell variant. The asterisk indicates papillary thyroid carcinoma excluding tall cell variant. IDH Mt, IDH1 mutant; IDH WT, IDH1 wild type; TERT⁺, TERT alteration present.