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. Author manuscript; available in PMC: 2021 Jun 9.
Published in final edited form as: Nature. 2020 Dec 9;589(7842):474–479. doi: 10.1038/s41586-020-3008-z

Figure 2. TBG is a safer analog of iboga alkaloids.

Figure 2.

(a) Mouse HTR assays demonstrate that TBG is not hallucinogenic. The doses (mg/kg) of IBG and TBG are indicated. +Ctrl = 5-MeO-DMT (10 mg/kg). (b) Inhibition of hERG channels expressed in HEK293 cells. Error bars represent SD. (c) Unlike ibogaine, IBG and TBG do not increase the risk for arrhythmias in larval zebrafish. Sertindole (SI) was used as a positive control. (d) Representative images of zebrafish treated with compounds (100 μM) for 2 dpf. Scale bar = 1 mm. (e) Compound-induced malformation and death over time (n = 48 zebrafish for all treatment groups). (f) Activities at 5-HT2A and 5-HT2B receptors as measured by Gq-mediated calcium flux. Data represent percent 5-HT fold-over-basal response. Exact N numbers for each experimental condition are reported in the Source Data and Supplementary Table 1. Specific statistical tests, information on reproducibility, and exact p values are reported in the Methods and Supplementary Table 1.