Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 9;13:22. doi: 10.1186/s13073-021-00840-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Guild-based aggregation overcomes the pitfall of taxon-based analysis to reflect the variations in strain-specific responses. a and b together illustrate why guild-based aggregation method produces a more accurate representation of strain-level microbiome response to dietary intervention in a PWS study compared with taxon-based aggregation. a shows the abundance change of the 5 Eubacterium eligens strains over time. If taxon-based aggregation is used, all 5 Eubacterium eligens strains could be collapsed into one species-level unit and represented by the black line in b. In contrast, using the guild-based aggregation method, the same 5 Eubacterium eligens strains are grouped into 3 different guilds (#1, #12, and #13). Each of the colored lines in b represents the abundance change over time of one guild. Abundance change pattern of the three guilds in b accurately captures the three types of abundance change patterns among the 5 Eubacterium eligens illustrated in a. The dots on each line in a and b represent the mean abundance (see S.E.M in Supplementary Table 1)