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. Author manuscript; available in PMC: 2021 Feb 10.
Published in final edited form as: Neuron. 2018 Aug 16;99(5):969–984.e7. doi: 10.1016/j.neuron.2018.07.030

Fig 3. D1R Suppresses Evoked Axonal Calcium Influx in PFC.

Fig 3

A) Long-range axon imaging configuration. Left: Schematic of recording. Injection site in green, stimulation and imaging location in red box. Middle: Example fluorescence response of axonal boutons. Red fluorescence was used to locate boutons, green fluorescence was monitored in response to electrical stimulation. Arrows highlight two boutons quantified in right panel. Right: Normalized change in fluorescence for example boutons from middle panels.

B) Evoked gCaMP6f signals in PFC boutons. SKF-mediated suppression was blocked by SCH23390.

C) Summary of change in peak ΔF/F in response to D1R activation for different long-range iputs to PFC (colors as in Figs. 1–2).

D) Summary of modulation of peak ΔF/F responses from cPFC axonal boutons with vehicle application or D1R activation in presence of D1R antagonist SCH23390.