Table 2.
Target pathways in top 1000 miRNA-mRNA interactions
| ID | Pathway | miRNA targets | P value |
|---|---|---|---|
| 1 | Phototransduction | CNGB1;GNAT1;GNAT2;GNGT1;GUCA1A;GUCY2F;RCVRN;RHO;GUCA1C | 1.85E-06 |
| 2 | Chemokine signaling pathway | ADCY1;GNB3;GNGT1;HCK;ITK;PRKCD;CCL4;CCL5;CXCL11;VAV2;CXCL14;CXCR6;GNG13; | 4.36E-05 |
| 3 | Ribosome | RPL10A;RPL3;RPL11;RPL22;RPL35A;RPS8;RPS23;RPS27A | 7.13E-04 |
| 4 | Phenylalanine metabolism | DDC;HPD;MAOB | 2.25E-03 |
| 5 | Cytokine-cytokine receptor interaction | TNFRSF8;CSF2RB;CTF1;IL2RB;IL12RB1;LTB;NGFR;CCL4;CCL5;CXCL11;TNFRSF1B;CXCL14;CXCR6;TNFRSF19;RELT | 5.02E-03 |
| 6 | Long-term depression | GRIA1;GRIA3;GRID2;GRM5;IGF1;RYR1 | 2.33E-02 |
| 7 | Primary immunodeficiency | LCK;PTPRC;TAP1;ZAP70 | 3.74E-02 |
| 8 | Cell adhesion molecules (CAMs) | HLA-F;PECAM1;PTPRC;SDC2;SIGLEC1;CNTNAP1;CADM1;CNTNAP2;CADM3 | 3.85E-02 |
| 9 | Amyotrophic lateral sclerosis (ALS) | DAXX;GRIA1;MAPK12;TNFRSF1B;DERL1 | 3.91E-02 |
| 10 | Tyrosine metabolism | DDC;HPD;MAOB;HEMK1 | 4.77E-02 |
| 11 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | EXT1;EXTL1;NDST4 | 4.79E-02 |
| 12 | Neuroactive ligand-receptor interaction | CHRNA3;CHRNA4;CHRNB3;EDNRB;GABRA1;GABRA3;GABRG2;GRIA1;GRIA3;GRID2;GRIK1;GRM5;HTR2B;MC2R | 4.91E-02 |
The p-values have been corrected based on Benjamini & Hochberg method. P<0.01 was considered as the threshold of significance.