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Knockdown of PAQR6 significantly suppressed the activation of the MAPK signaling pathway. (A) The protein expression of p-MEK, MEK, p-ERK, and ERK in DU145 cells was determined by western blot. (B) Quantification of the ratio of p-MEK/MEK, p-ERK/ERK obtained by western blot. Columns, mean (n= 6); bars, SD. **P<0.01, vs. expression of these proteins in DU145 cells transfected with scramble siRNA (si-con).
