. 2018 Dec 31;13:561–568. doi: 10.1515/biol-2018-0067

Table 5.

Changes in serum GPBB, Mb and BNP levels and in the values of echocardiogram indexes among four groups after chemotherapy

	< 150mg/m² (n = 39)	150 ~ 300mg/m² (n = 23)	300 ~ 450mg/m² (n = 29)	> 450mg/m² (n = 38)	F	p
GPBB
Before chemotherapy	22.34 ± 7.29	22.74 ± 5.60	23.06 ± 8.31	22.08 ± 4.39	0.139	0.936
After chemotherapy	23.68 ± 4.12	29.86 ± 4.03^*@	33.68 ± 4.79^*&@	42.06 ± 5.44^*&#@	101.8	< 0.001
Mb
Before chemotherapy	29.56 ± 10.07	31.46 ± 12.74	33.78 ± 15.65	32.35 ± 12.72	0.660	0.578
After chemotherapy	31.93 ± 12.64	44.66 ± 15.30^*@	59.82 ± 9.80^*&@	52.05 ± 13.76^*@	29.22	<0.001
BNP
Before chemotherapy	31.20 ± 14.41	29.61 ± 16.91	28.77 ± 13.22	31.98 ± 15.65	0.306	0.821
After chemotherapy	51.74 ± 15.10^@	70.02 ± 25.06^*@	88.45 ± 23.71^*&@	75.53 ± 30.92^*@	13.6	<0.001
LVEF
Before chemotherapy	55.27 ± 5.66	57.03 ± 5.71	55.91 ± 5.33	57.36 ± 4.97	1.147	0.333
After chemotherapy	59.20 ± 3.97^@	54.50 ± 4.09^*	51.07 ± 3.61^*&@	47.81 ± 5.39^*&#@	46.33	< 0.001
E/A
Before chemotherapy	1.28 ± 0.33	1.30 ± 0.33	1.22 ± 0.36	1.27 ± 0.29	0.347	0.792
After chemotherapy	1.13 ± 0.05^@	1.13 ± 0.04^@	1.12 ± 0.06	1.10 ± 0.08^@	1.948	0.125
EDT/ms
Before chemotherapy	173.64 ± 36.53	172.26 ± 42.26	171.94 ± 29.29	173.81 ± 36.10	0.022	0.996
After chemotherapy	189.83 ± 23.03^@	197.72 ± 28.55^@	189.28 ± 22.07^@	191.74 ± 29.09^@	0.572	0.634
IVRT/ms
Before chemotherapy	81.76 ± 12.35	82.49 ± 6.90	81.91 ± 10.36	82.07 ± 11.66	0.023	0.995
After chemotherapy	68.24 ± 20.40^@	68.71 ± 14.01^@	68.57 ± 17.97^@	68.23 ± 14.74^@	0.006	0.999

Note: GPBB, glycogen phosphorylase isoenzyme BB; Mb, myoglobin; BNP, brain natriuretic peptide; LVEF, left ventricular ejection fraction; E/A, mitral ratio of peak early to late diastolic filling velocity; IVRT, isovolumic relaxation time; EDT, E-wave deceleration time. ^*, p < 0.05 vs group of < 150mg/m²; ^&, p < 0.05 vs group of 150 ~ 300mg/m²; ^#, p < 0.05 vs group of 300 ~ 450mg/m^{2; @}, p < 0.05 vs levels or values before chemotherapy.