Fig. 2.

Mechanisms of action of tumour antigen‐targeting antibodies. Tumour antigen‐targeting (tumour‐depleting) antibodies mediate tumour cell‐killing via different mechanisms: (1, 2) activation of immune effector cells [antibody‐dependent cell‐mediated cytotoxicity (ADCC), antibody‐dependent cell‐mediated phagocytosis (ADCP)], (3) initiation of complement cascade [complement‐dependent cytotoxicity (CDC)], (4) blocking important signalling pathways in tumour cells and (5) formation of immune complexes inducing enhanced tumour antigen cross‐presentation by dendritic cells (DCs), leading to adaptive immune response.