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. 2021 Feb 10;23:100531. doi: 10.1016/j.imu.2021.100531

Table 3.

Predicted drug targets for Indinavir, Sorivudine Cidofovir and Darunavir.

Drugs Drug Targets Common Name Uniprot ID ChEMBL ID Target Class Probability*
Indinavir Multidrug and toxin extrusion protein 1 SLC47A1 Q96FL8 CHEMBL1743126 Electrochemical transporter Image 2
Multidrug and toxin extrusion protein 2 SLC47A2 Q86VL8 CHEMBL1743127 Electrochemical transporter Image 3
Neurokinin 2 receptor TACR2 P21452 CHEMBL2327 Family A G protein-coupled receptor Image 4
Renin REN P00797 CHEMBL286 Protease Image 5
Sorivudine Thymidine kinase, cytosolic TK1 P04183 CHEMBL2883 Transferase Image 6
Cytidine deaminase CDA P32320 CHEMBL4502 Enzyme Image 7
Thymidine kinase, mitochondrial TK2 O00142 CHEMBL4580 Enzyme Image 8
Cidofovir Thymidine phosphorylase TYMP P19971 CHEMBL3106 Enzyme Image 9
Hypoxanthine-guanine phosphoribosyltransferase HPRT1 P00492 CHEMBL2360 Enzyme Image 10
Purine nucleoside phosphorylase PNP P00491 CHEMBL4338 Enzyme Image 11
Darunavir Cathepsin D CTSD P07339 CHEMBL2581 Protease Image 12
Cytochrome P450 3A4 CYP3A4 P08684 CHEMBL340 Cytochrome P450 Image 13
Complement factor D CFD P00746 CHEMBL2176771 Protease Image 14