Table 3.
The Factorial Design Analysis Data of the Responses of NFX-Loaded PLGA NPs
| Responses | Sum of Squares | Mean Sum of Squares | F value | R² | Adjusted R² | Predicted R² | Adequate Precision |
|---|---|---|---|---|---|---|---|
| Ps | 94,188.875 | 23,547.2188 | 110.564 | 0.993 | 0.984 | 0.952 | 26.4711 |
| ZP | 74.923 | 18.731 | 34.184 | 0.979 | 0.949 | 0.847 | 17.502 |
| EE% | 1955.875 | 488.969 | 23.484 | 0.969 | 0.928 | 0.779 | 13.729 |
| Q30min | 124.677 | 31.169 | 16.447 | 0.956 | 0.898 | 0.689 | 11.952 |
| Q12h | 732.5 | 183.125 | 4.381 | 0.853 | 0.658 | 0.039 | 5.527 |
| P30min | 161.058 | 40.265 | 189.826 | 0.996 | 0.991 | 0.972 | 40.929 |
| P12h | 586.893 | 146.723 | 4.777 | 0.864 | 0.683 | 0.035 | 5.779 |
Abbreviations: NFX, norfloxacin; PLGA, Poly(lactic-co-glycolic acid); NP, nanoparticle; PS, particle size; ZP, zeta potential, EE%, drug entrapment efficiency percentage; Q30min, drug percentage released after 30 minute; Q12h, drug percentage released after 12 hours; P30min, drug percentage permeated after 30 minutes; P12h, drug percentage permeated after 12 hours.