(Left column) Reflective-mode geometry configuration for desorption electrospray ionization (Reprinted with permission from Ifa et al., 2010, copyright 2010 The Royal Society of Chemistry), direct analysis in real time (Adapted and modified with permission from Hajslova et al., 2011, copyright 2010 Elsevier Ltd.), and low-temperature plasma ionization sources (Reprinted with permission from Harper et al., 2008, copyright 2008 American Chemical Society). (Right column) Transmission-mode geometry configurations for desorption electrospray ionization (Reprinted with permission from Chipuk et al., 2010b, copyright 2009 American Chemical Society), direct analysis in real time (Reprinted with permission from Gómez-Ríos et al., 2017b, copyright 2017 The Royal Society of Chemistry), and low-temperature plasma ionization sources (Reprinted with permission from Zhao et al., 2016, copyright 2016 American Chemical Society).