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Adjusted time to event curves for CVD hospitalizations for new tramadol and other opioid use vs. no opioids. Curves were regression adjusted with variables from Table 2. Tramadol vs. no opioids HR 1.41, P < 0.0001; other opioids vs. no opioids HR 1.66, P < 0.0001; Tramadol vs. other opioids HR 0.85, P < 0.0001. CVD, cardiovascular disease; HR, hazard ratio.
