Figure 6.

A proposed molecular mechanism of the role of hepatic Argonaute 2 (Ago2) in obesity, post bariatric surgery, and in peroxisome proliferator–activated receptor α (PPARα) response. Hepatic Ago2 is required for the expression of metabolic disease–associated microRNA (MD-miRNA), which is enhanced in obesity but suppressed post bariatric surgery. Hepatic Ago2-dependent RNA silencing plays a critical role in gene regulation relevant to mitochondrial functions, including PPARα, adenosine 5′-monophosphate–activated protein kinase α (AMPKα1), and PPAR γ coactivator (PGC1α), and PPARα-mediated oxidative metabolism in obesity, post–vertical sleeve gastrectomy (VSG), and PPARα response.