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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Thorax. 2020 Jul 6;75(9):780–790. doi: 10.1136/thoraxjnl-2019-214187

Figure 4.

Figure 4

Similarity in sputum microbial communities between ‘responders’ and ‘non-responders’ to tobramycin. (A) Principal component analysis using the Aitchison dissimilarity metric of all baseline samples (small dots) coloured and grouped by response status. Large dots represent the centroid of each group, with lines connecting individual sample dots to their respective centroids. (B) Principal component analysis using the Aitchison dissimilarity metric of changes in relative abundance between baseline and week 1 samples (small dots) coloured and grouped by response status. Large dots represent the centroid of each group, with lines connecting individual sample dots to their respective centroids. PERMANOVA is a statistical test for difference between centroids, Homogeneity of Variance is a statistical test which assessed the difference in spread between two groups. (C–D) Difference in relative abundance (C) and calculated absolute abundance (D) of Pseudomonas aeruginosa and Staphylococcus aureus at baseline between ‘responders’ and ‘non-responders’. Boxes represent interquartile region and middle lines represent the medians.