Table 3. Genetic alteration profiles associated with Breslow thickness and ulceration in acral melanoma.
| Category | BRAF | NRAS | KIT amplification | TERT promoter | ||||
|---|---|---|---|---|---|---|---|---|
| Yes | No | Yes | No | Yes | No | Yes | No | |
| Heel, forefoot, hallux | ||||||||
| Breslow thickness | ||||||||
| ≤1 | 1 (20.0) | 9 (27.3) | 0 | 10 (29.4) | 0 | 9 (33.3) | 1 (33.3) | 7 (28.0) |
| >1.0~2.0 | 1 (20.0) | 10 (30.3) | 1 (25.0) | 10 (29.4) | 2 (50.0) | 6 (22.2) | 1 (33.3) | 2 (8.0) |
| >2.0~4.0 | 0 | 6 (18.2) | 2 (50.0) | 4 (11.8) | 0 | 2 (7.4) | 0 | 6 (24.0) |
| >4 | 3 (60.0) | 8 (24.2) | 1 (25.0) | 10 (29.4) | 1 (66.6) | 10 (37.0) | 1 (33.3) | 10 (40.0) |
| p-value | 0.239 | 0.295 | 0.325 | 0.543 | ||||
| Ulceration | ||||||||
| Yes | 2 (66.7) | 13 (43.3) | 2 (50.0) | 13 (44.8) | 2 (66.6) | 10 (43.5) | 0 | 11 (52.4) |
| No | 1 (33.3) | 17 (56.7) | 2 (50.0) | 16 (55.2) | 1 (25.0) | 13 (56.5) | 2 (100.0) | 10 (47.6) |
| p-value | 0.579 | >0.999 | 0.425 | 0.478 | ||||
| Midfoot, lesser toes | ||||||||
| Breslow thickness | ||||||||
| ≤1 | 0 | 4 (50.0) | 0 | 4 (50.0) | 0 | 3 (50.0) | 0 | 0 |
| >1.0~2.0 | 0 | 2 (25.0) | 1 (100) | 1 (12.5) | 0 | 2 (33.3) | 0 | 3 (75.0) |
| >2.0~4.0 | 1 (100) | 2 (25.0) | 0 | 3 (37.5) | 0 | 1 (16.7) | 0 | 1 (25.0) |
| >4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| p-value | 0.222 | 0.556 | NA | NA | ||||
| Ulceration | ||||||||
| Yes | 0 | 1 (12.5) | 0 | 1 (12.5) | 0 | 0 | 0 | 0 |
| No | 1 (100) | 7 (87.5) | 1 (100) | 7 (87.5) | 1 (100) | 6 (100) | 1 (100) | 4 (100) |
| p-value | >0.999 | >0.999 | NA | NA | ||||
Values are presented as number (%).