Table 4. PTEN promoter hypermethylation associated with Breslow thickness and ulceration in acral melanoma.
| Category | PTEN promoter hypermethylation | ||
|---|---|---|---|
| Yes | No | p-value | |
| Heel, forefoot, hallux | |||
| Breslow thickness | 0.001* | ||
| ≤1 | 0 | 9 (33.3) | |
| >1.0~2.0 | 1 (11.1) | 8 (29.6) | |
| >2.0~4.0 | 0 | 6 (22.2) | |
| >4 | 8 (88.9) | 4 (14.8) | |
| Ulceration | 0.042* | ||
| Yes | 6 (75.0) | 7 (30.4) | |
| No | 2 (25.0) | 16 (69.6) | |
| Midfoot, lesser toes | |||
| Breslow thickness | 0.556 | ||
| ≤1 | 0 | 2 (25.0) | |
| >1.0~2.0 | 0 | 4 (50.0) | |
| >2.0~4.0 | 1 (100) | 2 (25.0) | |
| >4 | 0 | 0 | |
| Ulceration | 0.125 | ||
| Yes | 1 (100) | 0 | |
| No | 0 | 7 (100) | |
Values are presented as number (%). *Statistically significant (p<0.05).