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. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2020 Dec 10;14(1):e009254. doi: 10.1161/CIRCEP.120.009254

Figure 2. — Circadian expression of core circadian clock gene (ARNTL, DBP, NFIL3, NR1D1, and PER2) transcripts in failing human hearts. A) Data from F set 1, n=37. B) Data from F set 2, n=45. HASR; hours after sunrise. Gene transcript in upper left corner of each plot. Each data point (organized according to collection time in HASR) is calculated from (A, F set 1) the mean of 9 consecutive samples, with 37 datapoints calculated from 37 samples, or (B, F set 2) the mean of 11 consecutive samples, with 45 datapoints calculated from 45 samples. The best fit from partial Fourier-analysis (calculated using Chronosfit 1.06) is represented by the solid line. Approximate light/dark interval (based upon approximate yearly average length of night in Pittsburgh PA) is represented with dark-phase in gray.

Figure 2. — Circadian expression of core circadian clock gene (ARNTL, DBP, NFIL3, NR1D1, and PER2) transcripts in failing human hearts. A) Data from F set 1, n=37. B) Data from F set 2, n=45. HASR; hours after sunrise. Gene transcript in upper left corner of each plot. Each data point (organized according to collection time in HASR) is calculated from (A, F set 1) the mean of 9 consecutive samples, with 37 datapoints calculated from 37 samples, or (B, F set 2) the mean of 11 consecutive samples, with 45 datapoints calculated from 45 samples. The best fit from partial Fourier-analysis (calculated using Chronosfit 1.06) is represented by the solid line. Approximate light/dark interval (based upon approximate yearly average length of night in Pittsburgh PA) is represented with dark-phase in gray.