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(A) Proposed binding and steric interactions of 8 with the TRKA double mutant G595R and G667C and (B) proposed binding of 9 to the TRKA double mutant for which steric interactions are not predicted between G595R and G667C. The kinase is depicted in yellow ribbons.164 Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red; fluorine, cyan.
