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(A) Structural optimization from compound 22 to 22–3 and (B) cocrystal structure of compound 22–3 with TRKA (PDB ID 5JFX, 1.63 Å). The kinase is depicted in yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red; chlorine, green.
