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(A) Identification of compound 37–1 and (B) cocrystal structure of compound 37 and its binding mode in TRKA (PDB ID 4PMP, 1.8 Å). The kinase is depicted in yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red; fluorine, cyan; sulfur, yellow.
