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(A) Chemical structure of compound 39, (B) cocrystal structure of compound 39 in the allosteric pocket of TRKA (PDB ID 5KMI, 1.87 Å), and (C) interactions of compound 39 with surrounding residues. The kinase is depicted in yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red.
