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(A) Chemical structure of compound 40, (B) cocrystal structure of compound 40 in the allosteric pocket of TRKA (PDB ID 5KMK, 2.24 Å), and (C) interactions of compound 40 with surrounding residues. The kinase is depicted in yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red; fluorine, cyan.
