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(A) Chemical structure of compound 41, (B) cocrystal structure of 41 bound in the allosteric pocket of TRKA (PDB ID 5H3Q, 2.1 Å), and (C) interactions of compound 41 with surrounding residues. The kinase is depicted in yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red; fluorine, cyan.
