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. Author manuscript; available in PMC: 2021 Feb 10.
Published in final edited form as: J Med Chem. 2018 Sep 19;62(4):1731–1760. doi: 10.1021/acs.jmedchem.8b01092

Figure 4.

Figure 4.

(A) Identification of compounds 1–3, 1–4, and 1–5 and (B) cocrystal structure of compound 1–3 in TRKA (PDB ID 4AOJ, 2.75 Å). The kinase is depicted in yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, cyan.