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. Author manuscript; available in PMC: 2021 Feb 10.
Published in final edited form as: J Med Chem. 2018 Sep 19;62(4):1731–1760. doi: 10.1021/acs.jmedchem.8b01092

Figure 5.

Figure 5.

(A) Identification of 2–1 and (B) cocrystal structure of compound 2–1 in CDK-2/cyclin A (PDB ID 2WIH, 2.5 Å). The kinase is depicted in yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound atoms are colored as follows: carbon, orange; nitrogen, blue; oxygen, red.