Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 11;13(578):eabe8146. doi: 10.1126/scitranslmed.abe8146

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 2 — (A to C) African green monkeys were inoculated with γ-irradiated SARS-CoV-2 (n = 2) and euthanized at 3 dpi; eight animals were inoculated with SARS-CoV-2 isolate nCoV-WA1-2020. (D to F) Four of those were euthanized at 3 dpi. (G to I) The remaining four animals were euthanized at 10 dpi. Histological analysis was performed on lung tissue from all animals. (A) Lungs of animals inoculated with γ-irradiated SARS-CoV-2 were normal at 3 dpi. (B) This was further confirmed at high magnification. (C) No SARS-CoV-2 antigen could be detected in lungs from animals inoculated with γ-irradiated SARS-CoV-2. (D) Mildly thickened septa were observed at 3 dpi in animals inoculated with infectious SARS-CoV-2. (E) Alveolar septa are slightly thickened and more cellular at 3 dpi. (F) Cytoplasmic and membrane-associated viral antigen in pneumocytes at 3 dpi. (G) Discrete foci of interstitial pneumonia are apparent at the periphery of the lung at 10 dpi. (H) Alveolar edema (*), type II pneumocyte hyperplasia (arrowheads), increased alveolar macrophages (arrows), and infiltrating lymphocytes and neutrophils are observed at 10 dpi, as well as proliferative nodules associated with terminal airways resembling obstructive bronchiolitis (OB). (I) Rare viral antigen could be detected in mononuclear cells, presumably alveolar macrophages, with cytoplasmic debris (arrows) at 10 dpi; background blush is observed in alveolar proteinaceous fluid (*), but pneumocytes do not exhibit immunoreactivity (arrowheads). Magnification, ×20 (scale bars: 1 mm) (A to C) and ×400 (scale bars: 0.05 mm) (D to I).