Fig 10. Employing the tests of HippoUnit to monitor the behavior of a set of detailed data-driven models of hippocampal neurons at different stages of model development.

Models of four different cell types (pyramidal cells and continuous accommodating (int cAC), bursting accommodating (int bAC) and continuous non-accommodating (int cNAC) interneurons) of the rat hippocampal CA1 region were developed within the Human Brain Project by automated optimization using BluePyOpt. The tests of HippoUnit were used to evaluate and compare the behavior of the older (Migliore et al 2018) version and the new (v4) version of these models. The median, the interquartile range and the full range of the final scores achieved by the models of each cell type were calculated and the results of the two versions of the model set are compared. Asterisks indicate significant differences (*: p<0.05; **: p<0.01).