Table 2. Logistic regression model for higher scores for fatigue.
| Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|
| Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | ||
| POMS | |||||
| Age | 1.001 (0.975 to 1.028) | 0.92 | 0.981 (0.950 to 1.014) | 0.25 | |
| Male gender | 0.551 (0.285 to 1.063) | 0.08 | 0.729 (0.336 to 1.579) | 0.42 | |
| Dialysis duration * | 1.106 (0.872 to 1.403) | 0.41 | 1.032 (0.724 to 1.471) | 0.86 | |
| Employed | 0.602 (0.333 to 1.088) | 0.09 | 0.668 (0.321 to 1.391) | 0.28 | |
| Smoker | 0.655 (0.241 to 1.781) | 0.41 | |||
| Dialysis modality | |||||
| HD | Ref. | Ref. | |||
| Online HDF | 0.870 (0.342 to 2.215) | 0.77 | 0.760 (0.267 to 2.164) | 0.61 | |
| PD | 0.712 (0.278 to 1.823) | 0.48 | 1.013 (0.295 to 3.478) | 0.98 | |
| Combined therapy | 1.437 (0.439 to 4.699) | 0.55 | 1.913 (0.445 to 8.218) | 0.38 | |
| CVD | 0.766 (0.407 to 1.439) | 0.41 | 0.591 (0.288 to 1.216) | 0.15 | |
| Diabetes | 1.244 (0.642 to 2.410) | 0.52 | 1.976 (0.908 to 4.296) | 0.09 | |
| BMI | 0.922 (0.862 to 0.986) | 0.02 | 0.895 (0.825 to 0.970) | 0.01 | |
| Hemoglobin | 0.901 (0.704 to 1.153) | 0.41 | 0.820 (0.619 to 1.087) | 0.17 | |
| Creatinine | 1.037 (0.955 to 1.126) | 0.39 | |||
| Urea nitrogen | 0.996 (0.975 to 1.018) | 0.72 | |||
| Serum albumin | 1.057 (0.549 to 2.033) | 0.87 | 1.425 (0.566 to 3.587) | 0.45 | |
| CRP * | 0.979 (0.755 to 1.268) | 0.87 | |||
| β2 microglobulin | 1.004 (0.959 to 1.052) | 0.87 | |||
| Use of ESAs | 1.319 (0.546 to 3.182) | 0.54 | |||
| VAS | |||||
| Age | 0.992 (0.967 to 1.018) | 0.56 | 0.966 (0.934 to 0.998) | 0.04 | |
| Male gender | 0.910 (0.492 to 1.682) | 0.76 | 1.578 (0.744 to 3.351) | 0.24 | |
| Dialysis duration * | 1.173 (0.928 to 1.483) | 0.18 | 1.384 (0.964 to 1.986) | 0.08 | |
| Employed | 0.466 (0.260 to 0.832) | 0.01 | 0.370 (0.176 to 0.776) | <0.01 | |
| Smoker | 1.186 (0.423 to 3.327) | 0.75 | |||
| Dialysis modality | |||||
| HD | Ref. | Ref. | |||
| Online HDF | 0.769 (0.314 to 1.884) | 0.57 | 0.629 (0.229 to 1.728) | 0.37 | |
| PD | 0.938 (0.378 to 2.324) | 0.89 | 1.166 (0.342 to 3.978) | 0.81 | |
| Combined therapy | 1.821 (0.582 to 5.698) | 0.30 | 1.651 (0.399 to 6.837) | 0.49 | |
| CVD | 0.820 (0.441 to 1.524) | 0.53 | 0.636 (0.312 to 1.295) | 0.21 | |
| Diabetes | 0.963 (0.509 to 1.822) | 0.91 | 1.060 (0.498 to 2.256) | 0.88 | |
| BMI | 0.964 (0.903 to 1.028) | 0.27 | 0.959 (0.887 to 1.038) | 0.30 | |
| Hemoglobin | 1.129 (0.887 to 1.436) | 0.33 | 1.065 (0.808 to 1.404) | 0.65 | |
| Creatinine | 1.039 (0.962 to 1.122) | 0.33 | |||
| Urea nitrogen | 0.986 (0.965 to 1.007) | 0.20 | |||
| Serum albumin | 0.612 (0.319 to 1.175) | 0.14 | 0.713 (0.285 to 1.787) | 0.47 | |
| CRP * | 1.192 (0.919 to 1.546) | 0.19 | |||
| β2 microglobulin | 1.041 (0.993 to 1.090) | 0.10 | |||
| Use of ESAs | 0.682 (0.28 to 1.661) | 0.40 | |||
| Our original scale of fatigue | |||||
| Age | 1.014 (0.986 to 1.043) | 0.34 | 0.984 (0.95 to 1.020) | 0.38 | |
| Male gender | 0.855 (0.432 to 1.689) | 0.65 | 1.258 (0.544 to 2.907) | 0.59 | |
| Dialysis duration * | 1.138 (0.884 to 1.464) | 0.32 | 1.136 (0.770 to 1.677) | 0.52 | |
| Employed | 0.394 (0.203 to 0.762) | 0.01 | 0.433 (0.190 to 0.987) | 0.047 | |
| Smoker | 0.319 (0.116 to 0.877) | 0.03 | 0.373 (0.113 to 1.226) | 0.10 | |
| Dialysis modality | |||||
| HD | Ref. | Ref. | |||
| Online HDF | 0.356 (0.111 to 1.147) | 0.08 | 0.422 (0.113 to 1.573) | 0.20 | |
| PD | 0.333 (0.103 to 1.080) | 0.07 | 0.649 (0.149 to 2.820) | 0.56 | |
| Combined therapy | 1.394 (0.279 to 6.953) | 0.69 | 1.994 (0.313 to 12.701) | 0.47 | |
| CVD | 0.936 (0.475 to 1.845) | 0.85 | 0.650 (0.289 to 1.464) | 0.30 | |
| Diabetes | 1.550 (0.743 to 3.233) | 0.24 | 1.625 (0.673 to 3.924) | 0.28 | |
| BMI | 0.974 (0.908 to 1.043) | 0.45 | 0.940 (0.861 to 1.026) | 0.17 | |
| Hemoglobin | 1.187 (0.910 to 1.549) | 0.21 | 0.973 (0.699 to 1.352) | 0.87 | |
| Creatinine | 0.976 (0.922 to 1.033) | 0.40 | |||
| Urea nitrogen | 1.006 (0.983 to 1.029) | 0.61 | |||
| Serum albumin | 0.942 (0.467 to 1.901) | 0.87 | 1.265 (0.452 to 3.535) | 0.65 | |
| CRP* | 1.183 (0.886 to 1.580) | 0.26 | |||
| β2 microglobulin | 1.032 (0.982 to 1.085) | 0.21 | |||
| Use of ESAs | 0.334 (0.095 to 1.173) | 0.09 | 0.222 (0.052 to 0.951) | 0.04 | |
Abbreviations: CI, confidence interval; POMS, Profile of Mood States; HD, hemodialysis; HDF, hemodiafiltration; PD, peritoneal dialysis; CVD, cardiovascular disease; BMI, body mass index; CRP, C-reactive protein; ESAs, erythropoiesis-stimulating agents; VAS, Visual Analogue Scale.
* Dialysis duration and CRP are log-transformed.