Table 5. Multiple regression model for the scales of fatigue in patients without depression.
| Variable | Unadjusted | Adjusted | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Regression coefficient | 95%CI | t value | p value | Regression coefficient | 95%CI | t value | p value | ||
| POMS (log-transformed) | |||||||||
| Age | 0.0015 | -0.0037 to 0.0066 | 0.56 | 0.58 | -0.0030 | -0.0098 to 0.0039 | -0.86 | 0.39 | |
| Male gender | -0.0692 | -0.1921 to 0.0538 | -1.11 | 0.27 | -0.0016 | -0.1460 to 0.1427 | -0.02 | 0.98 | |
| Dialysis duration * | 0.0171 | -0.0268 to 0.0611 | 0.77 | 0.44 | -0.0054 | -0.0665 to 0.0558 | -0.17 | 0.86 | |
| Employed | -0.1138 | -0.2257 to -0.0019 | -2.01 | 0.046 | -0.1117 | -0.2472 to 0.0239 | -1.63 | 0.11 | |
| Smoker | -0.103 | -0.312 to 0.107 | -0.97 | 0.33 | |||||
| Dialysis modality | |||||||||
| HD | Ref. | Ref. | |||||||
| Online HDF | -0.0618 | -0.2205 to 0.0970 | -0.77 | 0.44 | -0.0818 | -0.2587 to 0.0951 | -0.92 | 0.36 | |
| PD | -0.128 | -0.293 to 0.038 | -1.52 | 0.13 | -0.102 | -0.313 to 0.108 | -0.96 | 0.34 | |
| Combined therapy | 0.0510 | -0.1581 to 0.2601 | 0.48 | 0.63 | 0.0648 | -0.2027 to 0.3322 | 0.48 | 0.63 | |
| CVD | -0.0326 | -0.1560 to 0.0908 | -0.52 | 0.60 | -0.0750 | -0.2069 to 0.0569 | -1.13 | 0.26 | |
| Diabetes | -0.0223 | -0.1458 to 0.1012 | -0.36 | 0.72 | 0.0178 | -0.1232 to 0.1587 | 0.25 | 0.80 | |
| BMI | -0.0079 | -0.0201 to 0.0044 | -1.28 | 0.21 | -0.0090 | -0.0242 to 0.0062 | -1.17 | 0.24 | |
| Hemoglobin | -0.0309 | -0.0794 to 0.0176 | -1.26 | 0.21 | -0.0391 | -0.0927 to 0.0145 | -1.45 | 0.15 | |
| Creatinine | -0.00451 | -0.02416 to 0.01515 | -0.45 | 0.65 | |||||
| Urea nitrogen | -0.00011 | -0.00429 to 0.00407 | -0.05 | 0.96 | |||||
| Serum albumin | -0.0165 | -0.1530 to 0.1200 | -0.24 | 0.81 | -0.0249 | -0.2159 to 0.1661 | -0.26 | 0.80 | |
| CRP * | 0.0036 | -0.0535 to 0.0608 | 0.13 | 0.90 | |||||
| β2 microglobulin | 0.00693 | -0.00259 to 0.01644 | 1.45 | 0.15 | |||||
| Use of ESAs | 0.0432 | -0.1237 to 0.2102 | 0.51 | 0.61 | |||||
| VAS | |||||||||
| Age | -0.081 | -0.434 to 0.273 | -0.45 | 0.65 | -0.393 | -0.858 to 0.071 | -1.68 | 0.10 | |
| Male gender | 4.22 | -4.08 to 12.52 | 1.01 | 0.32 | 5.82 | -3.69 to 15.33 | 1.21 | 0.23 | |
| Dialysis duration * | 1.31 | -1.65 to 4.27 | 0.88 | 0.38 | 1.22 | -2.83 to 5.27 | 0.6 | 0.55 | |
| Employed | -5.07 | -12.66 to 2.53 | -1.32 | 0.19 | -6.78 | -15.77 to 2.22 | -1.49 | 0.14 | |
| Smoker | -3.92 | -18.53 to 10.68 | -0.53 | 0.60 | |||||
| Dialysis modality | |||||||||
| HD | Ref. | Ref. | |||||||
| Online HDF | -5.77 | -16.24 to 4.71 | -1.09 | 0.28 | -6.21 | -17.85 to 5.43 | -1.06 | 0.29 | |
| PD | -6.80 | -17.79 to 4.19 | -1.22 | 0.22 | -4.45 | -18.38 to 9.49 | -0.63 | 0.53 | |
| Combined therapy | 8.29 | -5.82 to 22.40 | 1.16 | 0.25 | 7.29 | -10.32 to 24.90 | 0.82 | 0.41 | |
| CVD | 2.20 | -6.05 to 10.44 | 0.53 | 0.60 | 0.82 | -7.93 to 9.57 | 0.19 | 0.85 | |
| Diabetes | 4.22 | -4.09 to 12.52 | 1.01 | 0.32 | 6.81 | -2.52 to 16.14 | 1.45 | 0.15 | |
| BMI | -0.333 | -1.153 to 0.486 | -0.81 | 0.42 | -0.828 | -1.830 to 0.175 | -1.64 | 0.11 | |
| Hemoglobin | 2.33 | -0.91 to 5.58 | 1.42 | 0.16 | 1.07 | -2.48 to 4.62 | 0.6 | 0.55 | |
| Creatinine | 0.595 | -0.728 to 1.919 | 0.89 | 0.38 | |||||
| Urea nitrogen | -0.098 | -0.385 to 0.189 | -0.68 | 0.50 | |||||
| Serum albumin | -0.76 | -9.87 to 8.36 | -0.16 | 0.87 | -1.19 | -13.76 to 11.38 | -0.19 | 0.85 | |
| CRP * | 0.04 | -3.64 to 3.72 | 0.02 | 0.98 | |||||
| β2 microglobulin | 0.120 | -0.507 to 0.747 | 0.38 | 0.70 | |||||
| Use of ESAs | 0.01 | -11.14 to 11.16 | 0.00 | 1.00 | |||||
| Our original scale of fatigue | |||||||||
| Age | 0.00967 | -0.00787 to 0.02720 | 1.09 | 0.28 | -0.0117 | -0.0339 to 0.0105 | -1.05 | 0.30 | |
| Male gender | -0.105 | -0.523 to 0.314 | -0.49 | 0.62 | 0.100 | -0.360 to 0.560 | 0.43 | 0.67 | |
| Dialysis duration * | 0.0392 | -0.1111 to 0.1894 | 0.52 | 0.61 | 0.0968 | -0.0981 to 0.2916 | 0.98 | 0.33 | |
| Employed | -0.521 | -0.895 to -0.146 | -2.75 | 0.01 | -0.408 | -0.844 to 0.028 | -1.86 | 0.07 | |
| Smoker | -0.955 | -1.641 to -0.269 | -2.76 | 0.01 | -0.803 | -1.510 to -0.096 | -2.25 | 0.03 | |
| Dialysis modality | |||||||||
| HD | Ref. | ||||||||
| Online HDF | -0.420 | -0.944 to 0.104 | -1.59 | 0.12 | -0.422 | -0.990 to 0.146 | -1.47 | 0.14 | |
| PD | -0.311 | -0.858 to 0.237 | -1.12 | 0.26 | -0.107 | -0.783 to 0.570 | -0.31 | 0.76 | |
| Combined therapy | 0.543 | -0.1478 to 1.234 | 1.56 | 0.12 | 0.278 | -0.590 to 1.145 | 0.64 | 0.53 | |
| CVD | -0.103 | -0.522 to 0.316 | -0.49 | 0.63 | -0.323 | -0.744 to 0.098 | -1.52 | 0.13 | |
| Diabetes | 0.395 | -0.018 to 0.809 | 1.89 | 0.06 | 0.457 | -0.001 to 0.914 | 1.98 | 0.05 | |
| BMI | 0.0123 | -0.0294 to 0.0541 | 0.59 | 0.56 | -0.0064 | -0.0548 to 0.0420 | -0.26 | 0.79 | |
| Hemoglobin | 0.0224 | -0.1434 to 0.1882 | 0.27 | 0.79 | -0.0830 | -0.2561 to 0.0901 | -0.95 | 0.34 | |
| Creatinine | -0.0013 | -0.0681 to 0.0654 | -0.04 | 0.97 | |||||
| Urea nitrogen | -0.01070 | -0.02475 to 0.00335 | -1.51 | 0.13 | |||||
| Serum albumin | -0.353 | -0.804 to 0.098 | -1.55 | 0.12 | -0.229 | -0.849 to 0.390 | -0.73 | 0.46 | |
| CRP * | 0.113 | -0.067 to 0.293 | 1.25 | 0.22 | |||||
| β2 microglobulin | 0.0163 | -0.0153 to 0.0479 | 1.03 | 0.31 | |||||
| Use of ESAs | -0.350 | -0.913 to 0.214 | -1.23 | 0.22 | |||||
Abbreviations: CI, confidence interval; POMS, Profile of Mood States; HD, hemodialysis; HDF, hemodiafiltration; PD, peritoneal dialysis; CVD, cardiovascular disease; BMI, body mass index; CRP, C-reactive protein; ESAs, erythropoiesis-stimulating agents; VAS, Visual Analogue Scale.
* Dialysis duration and CRP are log-transformed.