Table 2. Differentially expressed muscle proteins (DEP) with increased expression comparing horses susceptible to recurrent exertional rhabdomyolysis with control.
| Gene ID | Protein name | DEP | DEP |
|---|---|---|---|
| Log2 FC | P-Value | ||
| Calcium regulation and sarcoplasmic reticulum | |||
| CA1 | carbonic anhydrase 1 | 1.55 | 1.00E-04 |
| CA2 | carbonic anhydrase 2 | 1.10 | 1.00E-04 |
| ANK1 | ankyrin-1 isoform X4 | 0.24 | 1.70E-04 |
| CALM2 | calmodulin | 0.20 | 1.00E-04 |
| HRC | sarcoplasmic reticulum histidine-rich calcium-binding protein | 0.19 | 4.70E-03 |
| CAPN1 | calpain-1 catalytic subunit | 0.19 | 1.00E-04 |
| VCP | transitional endoplasmic reticulum ATPase | 0.13 | 1.00E-04 |
| SRL | sarcolumenin isoform X1 | 0.10 | 1.00E-04 |
| CASQ1 | calsequestrin-1 | 0.09 | 3.00E-03 |
| RYR1* | ryanodine receptor | 0.07 | 2.73E-02 |
| ANXA6 | annexin A6 isoform X1 | 0.05 | 9.00E-03 |
| Protein alterations | |||
| UBE2V2 | ubiquitin-conjugating enzyme E2 variant 2 | 0.26 | 3.90E-04 |
| UBC | ubiquitin C | 0.26 | 6.50E-04 |
| PSMA4 | proteasome subunit alpha type-4 isoform X1 | 0.20 | 1.00E-03 |
| QDPR | dihydropteridine reductase isoform X1 | 0.18 | 9.50E-04 |
| GSN* | gelsolin | 0.15 | 1.00E-03 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.1 | 9.00E-03 |
| Antioxidants | |||
| PRDX2* | peroxiredoxin-2 isoform X1 | 1.08 | 1.00E-04 |
| SELENBP1 | selenium-binding protein 1 | 0.19 | 1.00E-04 |
| PRDX1 | peroxiredoxin-1 | 0.15 | 7.00E-03 |
| GLO1 | lactoylglutathione lyase | 0.10 | 3.00E-03 |
| Plasma membrane | |||
| ATP1A2* | sodium/potassium-transporting ATPase subunit alpha-2 | 0.26 | 1.00E-03 |
| DMD* | dystrophin isoform X11 | 0.16 | 1.00E-03 |
| SNTB1 | beta-1-syntrophin isoform X2 | 0.11 | 2.00E-04 |
| Glyco(geno)lysis | |||
| AGL* | Glycogen debrancher | 0.09 | 1.50E-04 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.09 | 2.00E-03 |
| PHKA1 | phosphorylase b kinase regulatory subunit alpha | 0.05 | 5.50E-03 |
| Heat shock proteins | |||
| ST13 | hsc70-interacting protein | 0.08 | 8.00E-03 |
| Other | |||
| EIF4A2 | eukaryotic initiation factor 4A-II | 0.12 | 5.00E-03 |
| LOC106783470 | low quality protein | 0.80 | 2.00E-03 |
| LOC100147142 | low quality protein | 0.64 | 2.00E-03 |
Proteins are identified by their gene ID and protein name, FC indicates fold change. An asterisk indicates the encoding gene was also differentially expressed. Upregulated blood-born DEP are shown in S2 Table.