Table 3. Differentially expressed mitochondrial proteins (DEP) with decreased expression comparing horses susceptible to recurrent exertional rhabdomyolysis with control.
| Gene ID | Gene Name | DEP log2 FC | DEP P-Value | |
|---|---|---|---|---|
| Mitochondrial | ||||
| CKMT2 | creatine kinase S-type 2C | -0.23 | 1.00E-04 | |
| SLC25A4 | ADP/ATP translocase 1 | -0.18 | 1.00E-04 | |
| ACAT1 | acetyl-CoA acetyltransferase 2C | -0.18 | 1.00E-04 | |
| CHCHD3 | MICOS complex subunit MIC19 isoform X2 | -0.15 | 3.00E-03 | |
| PDHB | pyruvate dehydrogenase E1 component subunit beta 2C | -0.14 | 2.00E-03 | |
| VDAC3 | voltage-dependent anion-selective channel protein 3 isoform X1 | -0.14 | 4.00E-03 | |
| VDAC2 | voltage-dependent anion-selective channel protein 2 | -0.12 | 2.00E-03 | |
| MDH2 | malate dehydrogenase 2C | -0.13 | 5.60E-04 | |
| HADHA | trifunctional enzyme subunit alpha 2C | -0.13 | 1.00E-04 | |
| CS | citrate synthase 2C | -0.13 | 6.90E-04 | |
| CKM | creatine kinase M-type | -0.11 | 1.00E-04 | |
| SLC25A12 | calcium-binding mitochondrial carrier protein Aralar1 isoform X1 | -0.11 | 1.00E-04 | |
| VDAC1 | voltage-dependent anion-selective channel protein 1 | -0.10 | 1.10E-04 | |
| NNT | NAD(P) transhydrogenase 2C mitochondrial isoform X1 | -0.09 | 1.00E-04 | |
| ACADVL | very long-chain specific acyl-CoA dehydrogenase 2C soform X6 | -0.09 | 3.20E-04 | |
| TUFM | elongation factor Tu 2C | -0.08 | 2.00E-03 | |
| ACO2 | aconitate hydratase 2C | -0.07 | 1.00E-03 | |
| PDHA1 | pyruvate dehydrogenase E1 component subunit alpha 2C somatic form 2C | -0.06 | 1.10E-02 | |
| PHB2 | prohibitin-2 | -0.05 | 3.00E-03 | |
| Complex I NADH dehydrogenase [ubiquinone] | ||||
| NDUFB11* | 1 beta subcomplex subunit 11 2C | -0.34 | 3.70E-04 | |
| NDUFA3* | 1 alpha subcomplex subunit 3 | -0.19 | 6.00E-03 | |
| NDUFS8* | iron-sulfur protein 8 2C | -0.19 | 1.00E-02 | |
| NDUFA2 | 1 alpha subcomplex subunit 2 | -0.17 | 3.00E-03 | |
| NDUFB5* | 1 beta subcomplex subunit 5 2C | -0.17 | 2.00E-03 | |
| NDUFS3* | iron-sulfur protein 3 2C isoform X1 | -0.15 | 3.20E-04 | |
| NDUFA9 | 1 alpha subcomplex subunit 9 2C | -0.80 | 1.20E-02 | |
| NDUFA9 | 1 alpha subcomplex subunit 9 2C | -0.08 | 1.20E-02 | |
| NDUFA10 | 1 alpha subcomplex subunit 102C isoform X1 | -0.10 | 1.00E-03 | |
| NDUFA13 | 1 alpha subcomplex subunit 13 | -0.11 | 9.00E-03 | |
| NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit 2C isoform X1 | -0.10 | 1.50E-04 | |
| Complex II | ||||
| SUCLA2 | succinate—CoA ligase [ADP-forming] subunit beta 2C | -0.13 | 1.00E-03 | |
| SUCLG1 | succinate—CoA ligase [ADP/GDP-forming] subunit alpha 2C isoform X1 | -0.13 | 5.00E-03 | |
| Complex III | ||||
| UQCRB | cytochrome b-c1 complex subunit 7 | -0.25 | 1.00E-04 | |
| LOC111767815 | cytochrome b-c1 complex subunit 8 | -0.16 | 5.00E-03 | |
| Complex IV | ||||
| COX6B1* | cytochrome c oxidase subunit 6B1 | -0.22 | 2.00E-03 | |
| COX5B* | cytochrome c oxidase subunit 5B 2C | -0.17 | 1.00E-03 | |
| COX5A* | cytochrome c oxidase subunit 5A 2C | -0.16 | 1.20E-04 | |
| COX4I1 | cytochrome c oxidase subunit 4 isoform 12C | -0.09 | 1.00E-03 | |
| Complex V | ||||
| ATP5IF1* | ATPase inhibitor 2Cisoform X1 | -0.38 | 1.00E-04 | |
| ATP5PF | ATP synthase-coupling factor 62C | -0.27 | 8.10E-04 | |
| ATP8 | ATP synthase F0 subunit 8 | -0.27 | 1.00E-03 | |
| ATP5PD | ATP synthase subunit d 2Cisoform X1 | -0.24 | 1.00E-04 | |
| ATP5PB | ATP synthase F(0) complex subunit B1 2C | -0.16 | 1.00E-04 | |
| ATP5ME | ATP synthase subunit e 2C | -0.15 | 2.00E-03 | |
| ATP5F1A | ATP synthase subunit alpha 2C | -0.14 | 1.00E-04 | |
| ATP5F1C | ATP synthase subunit gamma 2C isoform X3 | -0.12 | 4.00E-03 | |
| ATP5F1B | ATP synthase subunit beta 2C | -0.08 | 1.00E-03 | |
Proteins are identified by their gene ID and protein name, FC indicates fold change. An asterisk indicates the encoding gene was also differentially expressed.