Table 4. Differentially expressed nonmitochondrial proteins (DEP) with decreased expression comparing horses susceptible to recurrent exertional rhabdomyolysis with control.
| Gene Symbol | Gene Name | DEP log2 FC | DEP P-Value |
|---|---|---|---|
| MYL3 | myosin light chain 3 | -0.49 | 1.00E-04 |
| MYL2 | myosin regulatory light chain 2%2C ventricular/cardiac | -0.48 | 1.00E-04 |
| TNNC1 | troponin C 2C slow skeletal and cardiac muscles | -0.39 | 1.00E-04 |
| TNNI1 | troponin I 2C slow skeletal muscle | -0.39 | 1.00E-04 |
| MYH1 | myosin-1 isoform X1 | -0.29 | 1.00E-04 |
| TNNT1 | troponin T 2C slow skeletal muscle isoform X1 | -0.26 | 1.00E-04 |
| MYBPC1 | myosin-binding protein C 2C slow-type isoform X2 | -0.15 | 1.00E-04 |
| MYOZ1 | myozenin-1 | -0.14 | 1.00E-03 |
| CFL2 | cofilin-2 isoform X1 | -0.14 | 1.00E-03 |
| MYOT | myotilin isoform X1 | -0.09 | 1.00E-03 |
| FLNC | filamin-C isoform X1 | -0.05 | 1.00E-03 |
| ACTN3 | alpha-actinin-3 | -0.10 | 1.00E-04 |
| LOC100070523 | 10 kDa heat shock protein 2C mitochondrial isoform X2 | -0.25 | 1.00E-04 |
| HSPB1 | heat shock protein beta-1 | -0.19 | 1.00E-04 |
| CRYAB | alpha-crystallin B chain | -0.19 | 1.20E-04 |
| HSPA9 | stress-70 protein 2C mitochondrial | -0.08 | 1.00E-03 |
| MDH1 | malate dehydrogenase 2C cytoplasmic | -0.17 | 1.00E-04 |
| FBP2 | fructose-1 2C6-bisphosphatase isozyme 2 | -0.11 | 3.00E-03 |
| TPI1 | triosephosphate isomerase | -0.08 | 5.90E-03 |
| ALDH1A1 | retinal dehydrogenase 1 | -0.08 | 1.00E-04 |
| CKM | Creatine kinase-M | -0.11 | 1.00E-04 |
| ENO3 | beta-enolase | -0.07 | 1.10E-02 |
| ATP2A2 | sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 | -0.27 | 1.00E-04 |
| ANXA2 | annexin A2 isoform X1 | -0.24 | 3.40E-04 |
| MB | myoglobin | -0.31 | 1.00E-04 |
| KPNA3 | importin subunit alpha-4 isoform X1 | -0.28 | 3.00E-03 |
Proteins are identified by their gene ID and protein name, FC indicated fold change. The log2 fold change and P value are shown for the protein. An asterisk indicates that the encoding gene was also differentially expressed.