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. 2021 Jan 29;17(1):e1009240. doi: 10.1371/journal.ppat.1009240

Table 2. Enriched GO terms in overlapping and natural infection only cell populations.

Experimental AND Natural primary DENV-1 infection Natural primary DENV-1 infection ONLY
Cell type Rank GO term Description FE FDR GO term Description FE FDR
Conventional mono 1 0032020 ISG15-protein conjugation > 100 3.20E-02 0034344 regulation of type III interferon production > 100 1.30E-02
Conventional mono 2 0060700 regulation of ribonuclease activity > 100 5.92E-04 0035549 positive regulation of interferon-beta secretion > 100 2.42E-02
Conventional mono 3 0016185 synaptic vesicle budding from presynaptic endocytic zone membrane > 100 3.95E-02 0009597 detection of virus > 100 3.06E-02
Conventional mono 4 0035455 response to interferon-alpha > 100 1.15E-08 0035547 regulation of interferon-beta secretion > 100 3.03E-02
Conventional mono 5 0060337 type I interferon signaling pathway > 100 6.28E-25 0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus > 100 3.00E-02
Conventional mono 6 0071357 cellular response to type I interferon > 100 4.19E-25 0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent > 100 1.29E-03
Conventional mono 7 0034340 response to type I interferon > 100 8.74E-25 0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 94.78 2.35E-03
Conventional mono 8 0045071 negative regulation of viral genome replication > 100 2.03E-19 0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway 94.78 2.30E-03
CD16hi monos 1 0032020 ISG15-protein conjugation > 100 1.27E-02 0034344 regulation of type III interferon production > 100 6.83E-03
CD16hi monos 2 0016185 synaptic vesicle budding from presynaptic endocytic zone membrane > 100 1.59E-02 0035549 positive regulation of interferon-beta secretion > 100 1.11E-02
CD16hi monos 3 0140239 postsynaptic endocytosis > 100 2.31E-02 0009597 detection of virus > 100 1.29E-02
CD16hi monos 4 0098884 postsynaptic neurotransmitter receptor internalization > 100 2.25E-02 0035547 regulation of interferon-beta secretion > 100 1.26E-02
CD16hi monos 5 0070142 synaptic vesicle budding > 100 2.46E-02 0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus > 100 1.23E-02
CD16hi monos 6 0060337 type I interferon signaling pathway > 100 3.16E-16 1902741 positive regulation of interferon-alpha secretion > 100 2.56E-02
CD16hi monos 7 0071357 cellular response to type I interferon > 100 2.81E-16 1902739 regulation of interferon-alpha secretion > 100 2.51E-02
CD16hi monos 8 0099590 neurotransmitter receptor internalization > 100 4.18E-02 0071360 cellular response to exogenous dsRNA > 100 1.53E-03
Memory CD4 1 0035455 response to interferon-alpha > 100 4.30E-06 0002519 natural killer cell tolerance induction > 100 5.10E-03
Memory CD4 2 0035455 response to interferon-beta > 100 7.09E-08 0042270 protection from natural killer cell mediated cytotoxicity > 100 9.10E-03
Memory CD4 3 0060337 type I interferon signaling pathway > 100 1.73E-14 0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent > 100 3.11E-04
Memory CD4 4 0071357 cellular response to type I interferon > 100 1.30E-14 0060700 regulation of ribonuclease activity > 100 3.04E-04
Memory CD4 5 0034340 response to type I interferon > 100 1.90E-14 0032020 ISG15-protein conjugation > 100 1.17E-02
Memory CD4 6 0045071 negative regulation of viral genome replication > 100 1.24E-08 0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent > 100 5.99E-04
Memory CD4 7 0048525 negative regulation of viral process 89.11 3.23E-11 0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway > 100 5.87E-04
Memory CD4 8 1903901 negative regulation of viral life cycle 81.77 7.16E-08 2001187 positive regulation of CD8-positive, alpha-beta T cell activation > 100 1.71E-02
NK/NKT 1 0016185 synaptic vesicle budding from presynaptic endocytic zone membrane > 100 1.02E-02 0060700 regulation of ribonuclease activity > 100 8.34E-07
NK/NKT 2 0140239 postsynaptic endocytosis > 100 1.28E-02 0032069 regulation of nuclease activity > 100 1.62E-05
NK/NKT 3 0098884 postsynaptic neurotransmitter receptor internalization > 100 1.91E-02 0060337 type I interferon signaling pathway > 100 1.22E-12
NK/NKT 4 0035455 response to interferon-alpha > 100 1.87E-02 0071357 cellular response to type I interferon > 100 9.73E-13
NK/NKT 5 0070142 synaptic vesicle budding > 100 3.96E-08 0035455 response to interferon-alpha 96.53 2.38E-03
NK/NKT 6 0035456 response to interferon-beta > 100 2.14E-02 0034340 response to type I interferon 96.53 1.48E-12
NK/NKT 7 0060337 type I interferon signaling pathway > 100 8.49E-10 0045071 negative regulation of viral genome replication 87.19 2.11E-09
NK/NKT 8 0071357 cellular response to type I interferon > 100 8.20E-21 0060333 interferon-gamma-mediated signaling pathway 75.08 5.36E-09
CD8 EM 1 0016185 synaptic vesicle budding from presynaptic endocytic zone membrane > 100 1.21E-02 0060700 regulation of ribonuclease activity > 100 1.65E-04
CD8 EM 2 0140239 postsynaptic endocytosis > 100 1.77E-02 0016185 synaptic vesicle budding from presynaptic endocytic zone membrane > 100 1.54E-02
CD8 EM 3 0098884 postsynaptic neurotransmitter receptor internalization > 100 1.74E-02 0140239 postsynaptic endocytosis > 100 2.26E-02
CD8 EM 4 0035455 response to interferon-alpha > 100 4.36E-08 0098884 postsynaptic neurotransmitter receptor internalization > 100 2.22E-02
CD8 EM 5 0070142 synaptic vesicle budding > 100 1.94E-02 0070142 synaptic vesicle buddin > 100 2.61E-02
CD8 EM 6 0060337 type I interferon signaling pathway > 100 1.06E-22 0035455 response to interferon-alpha > 100 1.76E-05
CD8 EM 7 0071357 cellular response to type I interferon > 100 5.32E-23 0060340 positive regulation of type I interferon-mediated signaling pathway > 100 3.93E-02
CD8 EM 8 0035456 response to interferon-beta > 100 9.32E-10 0035457 cellular response to interferon-alpha > 100 3.86E-02