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In resting B cells, NIK is constitutively degraded. Upon engagement by CD40L, monomers of CD40 cluster to form CD40 trimers in membrane lipid rafts, which recruit downstream signaling molecules including TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. TRAFs transduce signals leading to activation of NF-κB1 and NF-κB2 as well as MAPK pathways (See details in text).
