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. Author manuscript; available in PMC: 2021 Feb 10.
Published in final edited form as: Adv Immunol. 2019 Feb 11;141:105–164. doi: 10.1016/bs.ai.2019.01.001

Figure 4. TLR4 signaling pathways.

Figure 4.

LPS binding protein (LBP) and MD2 facilitate the binding of LPS to CD14 and TLR4. TLR4 transduces signals via two pathways, namely, MyD88 dependent- and TRIF-dependent pathways, to activate NF-κB, MAPK and IRF3. (See details in text).