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. 2021 Feb 5;14(2):dmm046359. doi: 10.1242/dmm.046359

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Comparison of the AIRE/Aire locus in human, mouse and rat, and strategies to generate APECED rodent models. (A) Schematic representation of AIRE/Aire locus organization in human, mouse and rat, showing the different genetic contexts. (B) Summary of the strategies used to develop APECED mouse and rat models, providing the location of the genetic editing and its consequence for the Aire protein.