Fig. 2.

Knockdown of AMPK suppressed synphilin-1-induced hyperphagia in flies. Bar graph showing food intake of various flies as indicated (observed at 1 to 5 days post-eclosion). Knockdown of AMPK significantly reduced the daily food intake by ∼40% in non-transgenic flies. Knockdown of AMPK by the 25931 or 32371 AMPKα-RNAi siRNA lines almost reversed the synphilin-1-induced hyperphagia in transgenic flies. There were 60 flies in each group. Data are mean±s.e.m. *P<0.05 (ANOVA followed by Tukey's post-hoc test; significance between groups as indicated).